The study of rheological properties of the fatty ointment base for topical treatment of colds

In developing of ointment for topical treatment of colds the structural and mechanical properties of the ointment bases contained isopropyl palmitate, beeswax and solid fat in different concentrations have been studied. Amount of isopropyl palmitate 60% remained constant and the ratio of solid fat and bee wax was varied. In order to study thixotropic properties the curve of kinetics deformation of ointments has been constructed. It has been set that when increasing solid fat content in ointment composition and respectively decreasing beeswax the structural and mechanical properties of the base are reduced. The tested ointment bases possess thixotropic properties and plasticity and belong to the class of Bingham systems. Thus ointment with solid fat content of 8%, isopropyl myristate of 60% and beeswax of 32% is superior by its rheological characteristics to other formulations.